In the case of unexplained subfertility, who should be treated with IVF cycles?

“What should we to trying among expectant management and IVF treatment?”

INTRODUCTION:

The bilateral tubal blockage led to the starting of the clinical indications for IVF, which has now reached to unexplained subfertility, which does not have an identifiable cause (barrier) to conception. Not much evidence as results of from randomized controlled trials could say that these couples got any positive effect from IVF. What type of couples should look for more possibilities of ongoing pregnancy with the help of IVF in comparison to expectant management?

SUMMARY:

In a recent comparison, Eekelen et al1 compared results in couples having unexplained subfertility and undergoing IVF (n = 40921) from registry data to those couples who have a similar type of subfertility on expectant management. The couples on expectant management (just intercourse) consisted of a prospective nationwide Dutch cohort (n = 4875) as well as a retrospective regional cohort from Aberdeen, Scotland (n = 975). Couples who attempted for less than a year to conceive, tubal occlusion, cases of anovulation, severe or mild endometriosis or male subfertility were not included. Couples on expectant management and those who received IVF, their matching on the basis of their characteristics to control for confounding were done. A model called Cox proportional hazards was fitted by them which included patient characteristics, the process of IVF treatment as well as their interactions to calculate the possibility of conception of each individual in a year, either by expectant management or by following IVF for all sets of patient characteristics. Conception leading to ongoing pregnancy was the endpoint, which is defined as a foetus entering gestational age near 12 weeks. When the adjusted 1year possibility was calculated, it was found to be 47.9% (95% CI: 45.0–50.9) post IVF whereas after expectant management it was found to be 26.1% (95% CI: 24.2–28.0). Calculating the absolute difference resulted in being 21.8% (95%CI: 18.3–25.3) favouring IVF in terms of average adjusted 1-year chances of conception. Factors like duration of subfertility, female’s age and previous pregnancy record influenced the effectiveness of IVF. Although IVF was found to be useful for women under 40 years of age, in case of women over 34 years, the one-year possibility of an IVF conception fell gradually. In contrast, IVF was less effective in women aged 40 or more, and the absolute difference chance is 10% or less in comparison to expectant management. However, IVF was found to be less effective in partners having a short period of secondary subfertility (< 1 year) who were having 30% or more chances of neutral conception.

CONCLUSION:

In the case of unexplained subfertile couples, when the woman is under 40, the chances of conception are higher with IVF than expectant management. On the basis of judgements on the gain in comparison to that of expectant management for a couple, IVF should be used selectively.

REFERENCES:

1. R van Eekelen, N van Geloven, M van Wely, S Bhattacharya, F van der Veen, M J Eijkemans, D J McLernon. IVF for unexplained subfertility; whom should we treat?, Human Reproduction, dez072, https://doi.org/10.1093/humrep/dez072

SOURCE: 

https://www.indianfertilitysociety.org/fertility-news-volume-10-july-2019/

Mohak laparoscopy and infertility center, part of a multi specialty,advanced care facility, is the Best infertility hospital in indore. Mohak IVF is the best fertility center in Indore, India with advanced technology, interactive & caring hospitality and great success rate. The affordable ivf cost in indore makes it preferential for the couples in need of infertility treatment, Test-tube Baby treatment and IVF treatment. The IVF specialist, doctors and the professional staff of center offers IVF, andrology, embryology, assisted reproductive technology, ICSI treatment and also offers IVF financing at our fertility center.To book an appointment with the Doctors/ best IVF specialist at the best IVF center in MP, Indore, Visit: https://www.mohakivf.com/ivf-center-in-indore.htm or Call- 78980-47572 / 80852-77666.

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To More Post: 10Super-Foods that improves the sperm count and enhances fertility in males.

10 Super-Foods that improves the sperm count and enhances fertility in males

In life, at certain moment everyone desires of having babies. But when that desire does not get fulfilled, then you must try to know the reason behind it. If you are planning to have a baby and want to increase your chances, you should introduce these super-foods in your daily diet. Presenting list of such 10 super-foods that if you include in your diet will help you to improve your sperm count, sperm quality and your sexual life

1. Dark Chocolate- Considered as the best food to increase sperm count. It is made of cacao beans that are full of antioxidants. It also contains an enzyme called L-Arginine that increases the volume of your sperm.

2. Eggs- Eggs are rich in Vitamin E and protein that helps in the motility of the sperm. Eggs in general are known as the basic super food, also help in increasing sperm count. Consuming eggs also protects sperm from free radical, hence increases chances of fertilisation.

3. Spinach- We never take it seriously when we gets the suggestion to eat leafy vegetables but these are very good for our body as they help to regulate vital activities, additionally it contributes to sperm production, being rich in folic acid, helps in development of sperm.

4. Bananas- It is rich in magnesium, vitamin B1 and C, also contains a rare enzyme known as Bromelain. These all helps in increasing sperm production and boosting sperm motility. Banana is considered as super food because it also regulates the sex hormone and helps in cheering mood.

5. Walnut- Already known as brain food, being rich in omega-3 fatty acids, walnuts improve the vitality of sperm, also help in increasing the sperm count.

6. Red meat- It is great source of zinc, also a rich in folic acid and selenium helps to improve sperm health and assist in sperm production and mobility.

7. Pomegranates- These are well known to increase sex drive. Rich in antioxidants, they help to increase quality of sperm production.

8. Olive oil- It helps in keeping the bad cholesterol level low and enhances the oxygen flow to testicles helping in development of healthy sperm and improves the sperm count.

9. Berries- Goji berries, raspberries, strawberries, cranberries, etc., contains antioxidant, and anti-inflammatory nutrients that helps to improve the production and quality of sperm.

10. Carrots- It helps in increasing the motility and mobility of sperm, having beta-carotene. It can be consumed as salads raw, or cooked with vegetables.

Mohak laparoscopy and infertility center, part of a multi specialty advanced care facility, is the Best infertility hospital in Indore. Mohak IVF is the Best ivf center in Indore, India with advanced technology, interactive & caring hospitality and great success rate. The affordable IVF treatment cost makes it preferential for the couples in need of infertility treatment in indore , Test-tube Baby treatment, and IVF treatment. The IVF specialist in indore, doctors and the professional staff of center offers IVF, andrology, embryology, assisted reproductive technology, ICSI treatment and also offers IVF financing at our fertility center.

To book an appointment with the Doctors/ best IVF specialist at the best IVF center in MP, Indore

Visit: https://www.mohakivf.com or Call - 78980-47572 / 80852-77666

Please go through our social media :

like our page to no more about ivf 

Facebook :  https://www.facebook.com/MOHAK-IVF-1167147806785287/

Please do follow on Instagram 

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To Read More : :   Different types of blocked fallopian tubes

Mohak IVF- Best Test Tube Baby Center In Indore

IVF or In Vitro Fertilization, also known as Test Tube Baby is the most preferred assisted reproductive technology which is most effective in helping women pregnant.

In this, an egg is fertilized outside the body and thereafter implanting inside the uterus.

Data says that more than 8 million babies have been born using IVF (In-Vitro Fertilization) until now (2019).

IVF Facts you should know:

● When no other treatments worked after hitting, IVF (In-Vitro Fertilization) can still help

in conceiving.

● This is done by fertilizing the egg in a laboratory dish outside the body and then

implanting it in order to carry the pregnancy.

● By 2022, the Indian market for IVF services is projected to touch $775.9 million at a CAGR of 16.6 % from the year 2016 to 2022.

Normal pregnancy involves the penetration of sperm inside a women’s egg and fertilization after ovulation inside the body, once the production of the matured egg from the ovaries.

The fertilized egg starts developing by attaching itself to the womb or uterus wall. This process is known as natural conception.

However, in case a woman fails to achieve pregnancy naturally or without assistance, she can opt for fertility treatment.

Since the late 1970s, IVF has been in practice. 25th July 1978 is considered to be a Golden Day in the Medical Science when Louise Brown, the first “Test Tube Baby” was born. The procedure was completed with the collaboration of Robert Edwards and Patrick Step toe who are now considered to be the pioneers of IVF.

“Follicular Aspiration” is a minor surgical procedure by which the egg is collected. The collected egg is then kept together with the sperm and then stored in an environmentally regulated chamber. The sperm is expected to enter the egg after a few hours.

ICSI (Intracytoplasmic Sperm Injection) is the procedure in which the sperm is directly injected into the egg.

The fertilized egg transforms in an embryo after division. Among the best embryos, one or the two of them are selected for transfer.

To help the womb reach the lining of the embryo, the going to be a mother is given HCG (Human Chorionic Gonadotrophin) or progesterone.

In-vitro fertilization (IVF) is considered ideal for those (women) who could not conceive after

having regular unprotected intercourse or even after artificial insemination for 12 cycles. IVF

can be the ultimate option when the fallopian tubes of the woman are blocked.

Mohak IVF- Best infertility hospital in indore, part of a multi-specialty advanced care facility, is the best test tube baby center in indore. Mohak IVF is the best fertility center in Indore, India with advanced technology, interactive & caring hospitality and great success rate. The affordable IVF treatment cost makes it preferential for the couples in need of infertility treatment, Test-tube Baby treatment, and IVF treatment. The IVF specialist, doctors and the professional staff of center offers IVF, andrology, embryology, assisted reproductive technology, ICSI treatment and also offers IVF financing at our fertility center. To book an appointment with the Doctors/ best IVF specialist at the best IVF center in MP, Indore, Visit: https://www.mohakivf.com or Call- 78980–47572 / 80852–77666

Visit our Facebook Page : https://www.facebook.com/MOHAK-IVF-1167147806785287/

Read More : Different types of blocked fallopian tubes

Different types of blocked fallopian tubes

Female reproductive system has muscular tubes with the lining of delicate hair-like structures called the fallopian tubes. Working in both directions, this hair help an egg to gain motility and travel from the ovaries to the womb (uterus), as well as help sperm, come up from womb.

Fimbriae are the finger-like structures where each fallopian tube ends. The fimbriae’s role is to catch and guide an egg after the ovary releases it.

The fallopian tube being located near most of the fertilized eggs plays an important role in conception. In case of damage of any part of the fallopian tube, let's say by an infection or surgery, the scar tissue blocks them and it may lead to infertility.

The type of fallopian tube blockage depends on the root cause of the blockage and location of occurrence. It can be found out with the help of certain medical screenings.

Its types are:-

1.  Distal Tubal occlusion-This type of blockage occurs when the fallopian tube is obstructed at the end, which is closest to the ovary. Usually, it happens as an after effect of a sexually transmitted disease ‘Chlamydia Trachomatis.’ This medical condition is even termed as hydrosalpinx.

2.  Mid-segment blockage- This type of blockage occurs in the midsection of the fallopian tube. It might happen due to any operation or infection, as this area is more susceptible to tubal ligation damage.

3.  Proximal Tubal Occlusion - This blockage occurs due to an infection, inflammation or complexity from a past abortion, miscarriage or even a pelvic inflammatory disease(PID).In such blockages, the ending of the tube, which is close to the uterus is obstructed.

4. Chronic Salpingitis- It is a consequence of any inflammation or a microbial infection in the fallopian tube. If the infection isn’t treated properly, it develops acute salpingitis, in which the inner walls of the fallopian tube get stuck and turn red and inflated, ultimately causing irreversible damage to the tubes.

5.  Hematosalpinx - It a medical condition in which the fallopian tube starts bleeding, causing the build-up of blood clots inside the tube eventually leading to blockage.

6.  Pyosalpinx- In such type of blockage, the fallopian tube is entirely filled and usually swollen with pus.

7.  Hydrosalpinx- It is a condition in which some serious or clear fluid is filled inside the fallopian tubes. The obstruction may become inflated, giving it a shape like that of a sausage. Such condition eventually leads to the blockage of the tubes at the ends.

Blocked fallopian tubes can possibly be opened with the help of surgery. Although, it totally depends on the position of blockage and the extent of scarring.

Mohak IVF Centre, one of the Best Infertility Hospitals in Indore, india provides you International Standard Infertility Treatment along with assisted reproductive technologies like IUI, IVF, ICSI ,etc at affordable IVF treatment / Test tube Baby Treatment cost along with the satisfaction of being consulted by the most renowned IVF specialists/ Doctors in Indore ,M.P. Come join us in our voyage towards better healthcare facilities for infertile couples and experience the Best Infertility Treatment in Indore.

More Post: WHAT ISPCOS/PCOD?