Saturday, March 21, 2020

SEMEN FREEZING

Semen freezing is the procedure whereby spermatozoa are exposed to cryoprotectants and then cooling them to subzero temperature using liquid nitrogen. Frozen semen samples can be stored for many years while maintaining reasonable parameters of semen. Semen freezing helps in storage, supply or reserve of the human sperm for future use.

Sperm freezing is widely used and established method in humans and other species, it is very effective in Assisted Reproductive technology (ART) and fertility preservation in patients with cancer, before initiation of radiotherapy or chemotherapy. Semen freezing can be done by two methods 1. Noncontrolled rate cryopreservation and 2. Controlled rate cryopreservation.

CLINICAL APPLICATION OF SPERM FREEZING :-

1.Assisted Reproductive Technologies (ART)

2. Fertility Preservation with Cancer Therapy

3. Non- malignancy systemic diseases and other conditions

4. Surgical procedures involving male genitalia

5. Social and other reasons

ART – Assisted reproductive technologies – IUI/IVF/ICSI:

In ART, the most common use of sperm freezing is in artificial insemination, in vitro fertilization (IVF), or intra cytoplasmic sperm injections (ICSI) for various infertile couples. One of the ART options usually offered to infertile couples is intrauterine insemination using fresh or frozen sperm. Although the technique is used preferably with a fresh semen sample, the availability of freezing sperm samples is an option usually offered by infertility clinics in case the male partner cannot produce semen. In case of severe male factor infertility, the samples can be frozen for later use.

Fertility Preservation with Cancer Therapy:

Another application of sperm freezing is for cancer patients before initiation of cancer therapy. The option of sperm freezing should be offered to any male undergoing chemotherapy or radiotherapy as these treatments can have long-term or permanent cytotoxic side effects on testicular function. One of the advantages of semen freezing is here is that the frozen sperm can stand multiple freezing thawing cycles with no effect on the sperm quality; this is beneficial in cases where patients might have testicular cancer and require surgical removal of the whole testis, with no future possibility of obtaining sperm again. For young males before puberty , cryopreservation of testicular tissue may be an option for fertility preservation in future, improved chemotherapy regimens may give hope to patients in terms of maintaining their sexual and fertility potential after therapy, but at present all male patients diagnosed with cancer who wish to have children should consider sperm freezing or cryopreservation of testicular tissues for further ART use.

Non- malignancy systemic diseases and other conditions:

Cryopreservation of sperm or testicular tissue can also be used in patients prior to cytotoxic therapy for non malignant conditions, such as autoimmune diseases, kidney diseases, inflammatory bowel disease and heart transplant procedures. Most of these conditions are not fatal and the patients should be offered freezing of their sperm or testicular tissue prior to the cytotoxic therapy in order to preserve their fertility for the future.

Surgical procedures involving male genitalia:

Sperm freezing can also be used prophylactically before, during, or after certain surgical procedures as these may have serious adverse effects on male genital structure and functions. An example is the varicocele ligation procedure or reconstructive surgery (e.g. vasovasectomy or vasoepididmostomy). Sperm freezing may also be used postoperatively to insure against subsequent loss of patency of the vas deferens.

Social and other reasons:

Sperm freezing could be a mean of preserving fertility in men with social reasons to preserve their rights to have children bearing their names, for example soldiers being deployed to combat missions in war. Other reasons for sperm freezing might be immediately pre and postmortem where relatives of a person wish to ensure that the person can have a legal heir.

CONCLUSION:

Applications of sperm freezing now days are diverse and include humans, animals and insects. Despite the undeniable morphological and functional adverse effects that cryopreservation exerts on sperm, it still remains one of the core methods of fertility preservation for patients and healthy volunteer donors. Future studies are expected to concentrate on advancing technology to achieve the goal of “damage free” sperm after freezing. Encouragingly, recent advances in ART suggest that it will be possible eventually to achieve a healthy pregnancy and live birth from freezing of a single sperm or frozen semen sample. Nevertheless, it has proved to be boon in the era of modernization helping childless couples to embrace parenthood. Sperm freezing has become an accepted modality for fertility preservation and childless couples.


If you want to get infertility treatment in Indore in a low budget, then you should come Mohak Infertility Center. We provide IVF, IUI, ICSI, test tube baby, Embryo Donor, Cryopreservation / Sperm / Embryo Freezing etc. services at very low cost in Mohak Infertility Center. We have teams of many experienced ivf doctors. If you are also involved in childless couples, then one must come Mohak Infertility Center Indore. Book an appointment Call now 7898047572 For more information, visit - https://www.mohakivf.com


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Monday, March 9, 2020

OLIGOSPERMIA : ITS CAUSES SYMPTOMS AND TREATMENT

Oligospermia is a male fertility issue characterized by a low sperm count. Other aspects of the sexual health of men with this condition are typical. This includes the ability to get and maintain an erection, as well as produce ejaculation at orgasm.

Sperm count in your ejaculate can vary throughout your life. A healthy sperm amount is often necessary for fertility. The World Health Organization (WHO) classifies sperm counts at or above 15 million sperm per milliliter (mL) of semen as average. Anything below that is considered low and is diagnosed as oligospermia.
  • Mild oligospermia is 10 to 15 million sperm/mL.
  • Moderate oligospermia is considered 5 to 10 million sperm/mL.
  • Severe oligospermia is diagnosed when sperm counts fall between 0 and 5 million sperm/mL.
  • Some men with oligospermia can still conceive despite lower sperm counts. Fertilization may be more difficult, however. It may take more attempts than couples without a fertility issue.
  • Other men with oligospermia may have no problem with conception, despite the low sperm numbers.
Some of the most common causes of oligospermia also increase a man’s risk for other fertility issues. This includes sperm motility problems.

Sperm motility refers to how “active” sperm are in a man’s semen. Normal activity allows sperm to swim toward an egg for fertilization easily. Abnormal motility may mean the sperm don’t move enough to reach an egg. The sperm may also move in an unpredictable pattern that would prevent them from reaching an egg.

Causes of Oligospermia

There are many possible causes of oligospermia, including the following:
  • Varicocele – a swelling of the veins that drain the testicle
  • Infection that interferes with sperm production or sperm health
  • Ejaculation problems such as retrograde ejaculation (ejaculation backward into the bladder)
  • Certain medications (alpha blockers, finasteride, antiandrogens)
  • Genetic conditions (Y chromosome deletions, altered chromosomes)
  • Hormonal imbalance (low testosterone, high prolactin levels)
  • Undescended testicles
  • Medical issues such as multiple sclerosis, diabetes or thyroid disorders
  • Heat exposure (hot tubs, baths, saunas)
  • Recreational drugs (Alcohol, cocaine, marijuana)
  • Anabolic steroid use
  • Chronic stress
How to diagnose a  Oligospermia case

Doctor will take a detailed medical history and perform a general physical examination of your genitalia. He will also order a semen analysis and reproductive hormones that include testosterone, FSH and LH.

Low sperm count can be a biomarker of current and future health. If tests show you have a low sperm count, you should seriously consider undergoing a thorough medical evaluation with a specialist to rule out any underlying health conditions. You should also see your doctor annually to stay on top of your overall health and catch anything troubling early, when it is more easily treated.

Treatment

Oligospermia does not mean you have untreatable infertility. Docotr may recommend one of several approaches to improve semen quality.

Home remedies  

1- Track ovulation
2-Have sex more frequently
3- Don’t use lubricants

Treatment may include:

Surgery. For example, a varicocele can often be surgically corrected or an obstructed vas deferens can be repaired. Prior vasectomies can be reversed. In cases where no sperm are present in the ejaculate, sperm can often be retrieved directly from the testicles or epididymis using sperm retrieval techniques.
  • Treating infections. Antibiotics can cure an infection of the reproductive tract, but this doesn't always restore fertility.
  • Treatments for sexual intercourse problems. Medication or counseling can help improve fertility in conditions such as erectile dysfunction or premature ejaculation.
  • Hormone treatments and medications. Your doctor might recommend hormone replacement or medications in cases where infertility is caused by high or low levels of certain hormones or problems with the way the body uses hormones.
  • Assisted reproductive technology (ART). ART treatments involve obtaining sperm through normal ejaculation, surgical extraction or from donor individuals, depending on your specific situation and wishes. The sperm are then inserted into the female genital tract, or used for IVF or intracytoplasmic sperm injection.

Mohak Infertility Center Indore is one of the Best infertility treatment hospitals and Test tube baby centers. We offer fertility treatments at the most affordable cost in the shortest possible time with the highest success rate which only the Best IVF center in Indore can provide; that’s why we say that we are Best fertility hospital in Indore. Mohak Infertility Center is one of the leading & low-cost fertility treatment hospitals; we provide infertility specialist treatments or IVF treatment cost in Indore on best IVF packages and offers the lowest IVF price in Indore. The Mohak Infertility Center offers all best high-quality fertility treatment and services like In Vitro fertilisation (IVF), Intra Uterine Insemination (IUI), Intra Cytoplasmic Sperm Injection (ICSI),Egg / Sperm / Embryo Donor, Cryopreservation / Sperm / Embryo Freezing, Laparoscopy & Hysteroscopic, test tube baby and Ultrasound Scan etc. Dr Shilpa Bhandari has Reproductive Medicine specialist of Indore India. With his expertise, He has fulfilled many mothers’ hope including more than 5000+ successful Test Tube Babies till date. He has been rewarded with best IVF specialist in Indore, Madhya Pradesh and all over India because of his quality fertility services. Book an appointment Today Call now 7898047572, 8085-277666 For more information, visit - https://www.mohakivf.com


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